Anti-Human Jagged1/CD339 Rabbit Recombinant Antibody proteintech 98243-1-RR
$106.00
In stock
SKU
98243-1-RR
Jagged1, JAG1, Protein jagged-1, HJ1, CD339
| Host / Isotype: Rabbit / IgG | Class: Antibody |
| Reactivity: human | Immunogen: jagged 1 (Alagille syndrome) |
| Applications: FC | Observed Molecular Weight: BC098393 |
| Formulation: PBS, Azide | GenBank Accession Number: 182 |
| Conjugate: Unconjugated | Gene Symbol: Unconjugated |
| Tested Applications: Positive FC detected in | Gene ID (NCBI): Liquid |
| Application: Flow Cytometry (FC) | RRID: Protein A purfication |
| Dilution: FC : 0.25 ug per 10^6 cells in 100 μl suspension | Conjugate: P78504 |
| Tested Reactivity: Human | Form: PBS with 0.09% sodium azide, pH 7.3. |
| Host / Isotype: Recombinant | Background Information: Jagged1 (JAG1), also known as CD339, is a type I, membrane-anchored, multi-domain protein and a ligand of the Notch receptor (PMID: 15358557). Jagged1 is composed of a relatively small intracellular domain, a transmembrane domain, and a larger extracellular component containing a cystine-rich region, 16 EGF-like repeats, a DSL domain, and a signal peptide (PMID: 15358557; 26548814). It is widely expressed throughout mammalian development, across many tissues and developmental stages (PMID: 26548814). The Jagged1-NOTCH interaction can trigger the Notch signaling and activate transcription factors that play key roles in cell differentiation and morphogenesis. |
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