APP Monoclonal antibody proteintech 60342-1-Ig
$449.00
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60342-1-Ig
amyloid precursor protein, Alzheimer disease amyloid A4 protein homolog, AD1, AB42, AB40
| Host / Isotype: Mouse / IgG2a | Class: Monoclonal |
| Reactivity: Human, Rat, Pig, Rabbit And More (1) | Immunogen: CatNo: Ag0769 Product name: Recombinant human APP protein Source: e coli.-derived, PGEX-4T Tag: GST Domain: 1-305 aa of BC004369 Sequence: MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREKWYKEVHSGQARWLML Predict reactive species |
| Applications: WB, IHC, IF, IP, ELISA | Observed Molecular Weight: 87 kDa |
| Formulation: PBS, Azide, Glycerol | GenBank Accession Number: BC004369 |
| Conjugate: Unconjugated | Gene Symbol: APP |
| Tested Applications: Positive WB detected in | Gene ID (NCBI): 351 |
| Application: Western Blot (WB) | RRID: AB_2881451 |
| Dilution: WB : 1:1000-1:4000 | Conjugate: Unconjugated |
| Tested Reactivity: Human, Rat, Pig, Rabbit | Form: Liquid |
| Host / Isotype: Mouse / IgG2a | Background Information: Aβ derives from APP via proteolytic cleavage by proteases called α-, β- and γ-secretase. The α-secretase cleavage precludes the formation of Aβ, while the β- and γ-cleavages generate APP components with amyloidogenic features. Amyloid beta A4 precursor protein(APP), encoded by APP gene which locate on human chromosome 21q, is a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. APP expressed in all fetal tissues and is pronounced in brain, kidney, heart and spleen, but weak in liver. Defects in APP are the cause of Alzheimer disease type 1 (AD1). |
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