iNOS Polyclonal antibody proteintech 22226-1-AP
$449.00
In stock
SKU
22226-1-AP
NOS2, EC:1.14.13.39, Hepatocyte NOS, HEP-NOS, Inducible NO synthase
| Host / Isotype: Rabbit / IgG | Class: Polyclonal |
| Reactivity: Human, Mouse And More (2) | Immunogen: CatNo: Ag17567 Product name: Recombinant human NOS2 protein Source: e coli.-derived, PGEX-4T Tag: GST Domain: 1-190 aa of BC130283 Sequence: MACPWKFLFKTKFHQYAMNGEKDINNNVEKAPCATSSPVTQDDLQYHNLSKQQNESPQPLVETGKKSPESLVKLDATPLSSPRHVRIKNWGSGMTFQDTLHHKAKGILTCRSKSCLGSIMTPKSLTRGPRDKPTPPDELLPQAIEFVNQYYGSFKEAKIEEHLARVEAVTKEIETTGTYQLTGDELIFAT Predict reactive species |
| Applications: WB, IHC, IF, FC (Intra), CoIP, ELISA, Cell treatment | Observed Molecular Weight: 1153 aa, 131 kDa |
| Formulation: PBS, Azide, Glycerol | GenBank Accession Number: BC130283 |
| Conjugate: Unconjugated | Gene Symbol: iNOS |
| Tested Applications: Positive WB detected in | Gene ID (NCBI): 4843 |
| Application: Western Blot (WB) | RRID: AB_2879038 |
| Dilution: WB : 1:500-1:2000 | Conjugate: Unconjugated |
| Tested Reactivity: Human, Mouse | Form: Liquid |
| Host / Isotype: Rabbit / IgG | Background Information: NOS2, also named as iNOS and NOS2A, produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. NO is a reactive free radical which acts as a biologic mediator in several processes, including neurotransmission, antimicrobial and antitumoral activities. NOS2 is a nitric oxide synthase which is expressed in liver and is inducible by a combination of lipopolysaccharide and certain cytokines. iNOS has a very short half-life due to rapid degradation by calpain. iNOS monomer is a direct substrate of calpain I and can be cleaved by calpain I at the canonical CaM-binding site(503-532aa) of iNOS, and then a ~70kD band can be detected by western (PMID:11786228). |
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