Anti-Human CD72 Rabbit Recombinant Antibody proteintech 98090-1-RR
$67.00
In stock
SKU
98090-1-RR
241300C1, B-cell differentiation antigen CD72, CD72 molecule, CD72b, Lyb 2
| Host / Isotype: Rabbit / IgG | Class: Antibody |
| Reactivity: human | Immunogen: CD72 molecule |
| Applications: FC | Observed Molecular Weight: BC030227 |
| Formulation: PBS, Azide | GenBank Accession Number: 971 |
| Conjugate: Unconjugated | Gene Symbol: AB_3672237 |
| Tested Applications: Positive FC detected in | Gene ID (NCBI): Unconjugated |
| Application: Flow Cytometry (FC) | RRID: Liquid |
| Dilution: FC : 0.25 ug per 10^6 cells in a 100 ?l suspension | Conjugate: Protein A purfication |
| Tested Reactivity: Human | Form: P21854 |
| Host / Isotype: Recombinant | Background Information: CD72 is a type II transmembrane glycoprotein of 39-45 kDa and is expressed as a disulphide-linked homodimer (PMID: 1711157). CD72 is a pan B-cell marker covering the full range of differentiation from the very early stages of B cells to mature surface Ig+ B cells (PMID: 1384316). It is expressed in all stages of B cell development except plasma cells. CD72 is also expressed by dendritic cells, tissue macrophages in the red pulp of the spleen and von Kupffer cells in the liver (PMID: 8561576; 1384316). CD72 is the ligand for CD5 (PMID: 1711157). CD72 is a negative regulator of BCR signaling (PMID: 9590210). Interaction of CD100 with CD72 strictly tunes the strength of BCR signals and is essential for maintaining immunological homeostasis as well as generating a proper immune response (PMID: 16113236). |
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