Phospho-TAU (Thr231) Recombinant monoclonal antibody proteintech 80101-7-RR
$449.00
In stock
SKU
80101-7-RR
p TAU, p TAU (Thr231), p TAU Thr231, Phospho TAU, Phospho TAU (Thr231)
| Host / Isotype: Rabbit / IgG | Class: Recombinant |
| Reactivity: human, mouse | Immunogen: Peptide Predict reactive species |
| Applications: WB, IHC, IF-P, FC (Intra), ELISA | Observed Molecular Weight: 37-46, 79-81 kDa |
| Formulation: PBS, Azide, Glycerol | GenBank Accession Number: BC000558 |
| Conjugate: Unconjugated | Gene Symbol: TAU |
| Tested Applications: Positive WB detected in | Gene ID (NCBI): 4137 |
| Application: Western Blot (WB) | RRID: AB_3670466 |
| Dilution: WB : 1:1000-1:4000 | Conjugate: Unconjugated |
| Tested Reactivity: Human, Mouse | Form: Liquid |
| Host / Isotype: Rabbit / IgG | Background Information: Tau (tubulin-associated unit) is a microtubule-associated protein (also known as MAPT), expressed mainly in neurons of the central nervous system. Its primary function is to modulate microtubule dynamics for maintaining axonal cytoskeleton. The Tau protein has six isoforms produced from a single gene through alternative RNA splicing. Isoforms differ in number of inserts at the N-terminal half and the number of repeats at the C-terminal half (3 repeat-3R; 4 repeat-4R). Tau is hyperphosphorylated during aging and in age-related neurodegenerative diseases such as Alzheimer's disease (AD) and fronto-temporal dementia. Hyperphosphorylation of Tau leads to the formation of neurofibrillary tangles (NFT) in the neurons and glia cells, which is one of the hallmarks of AD. |
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