PTPRO Monoclonal antibody proteintech 67000-1-Ig
$449.00
In stock
SKU
67000-1-Ig
2F2B4, EC:3.1.3.48, GLEPP1, PTP U2, PTPase U2
| Host / Isotype: Mouse / IgG2b | Class: Monoclonal |
| Reactivity: Human, Pig And More (1) | Immunogen: CatNo: Ag8284 Product name: Recombinant human PTPRO protein Source: e coli.-derived, PET28a Tag: 6*His Domain: 298-597 aa of BC035960 Sequence: YWWDSASAAPESEDEFVSVLPMEYENNSTLSETEKSTSGSFSFFPVQMILTWLPPKPPTAFDGFHIHIEREENFTEYLMVDEEAHEFVAELKEPGKYKLSVTTFSSSGSCETRKSQSAKSLSFYISPSGEWIEELTEKPQHVSVHVLSSTTALMSWTSSQENYNSTIVSVVSLTCQKQKESQRLEKQYCTQVNSSKPIIENLVPGAQYQVVIYLRKGPLIGPPSDPVTFAIVPTGIKDLMLYPLGPTAVVLSWTRPYLGVFRKYVVEMFYFNPATMTSEWTTYYEIAATVSLTASVVIFP Predict reactive species |
| Applications: WB, IHC, IF-P, ELISA | Observed Molecular Weight: 138 kDa |
| Formulation: PBS, Azide, Glycerol | GenBank Accession Number: BC035960 |
| Conjugate: Unconjugated | Gene Symbol: PTPRO |
| Tested Applications: Positive WB detected in | Gene ID (NCBI): 5800 |
| Application: Western Blot (WB) | RRID: AB_2882317 |
| Dilution: WB : 1:500-1:2000 | Conjugate: Unconjugated |
| Tested Reactivity: Human, Pig | Form: Liquid |
| Host / Isotype: Mouse / IgG2b | Background Information: PTPRO(receptor-type tyrosine-protein phosphatase O) is also named as GLEPP1, PTPU2 and belongs to the protein-tyrosine phosphatase family. The protein is a receptor-like membrane protein tyrosine phosphatase expressed at the apical membrane of the podocyte foot processes in the kidney(PMID:21722858). The 1,159-amino acid predicted mature protein contains a large extracellular domain, a single transmembrane domain, and a single intracellular PTPase domain. Defects in PTPRO are the cause of nephrotic syndrome type 6 (NPHS6). In reducing conditions, PTPRO can form a smear from 180 to 220 kDa; In non-reducing conditions, a band appeares around 350 kDa, which likely represents the dimeric form of full-length PTPRO (PMID: 19573017). |
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