DeltaN p63 Recombinant monoclonal antibody proteintech 86154-11-RR
$449.00
In stock
SKU
86154-11-RR
p63, TP63, CUSP, TP 63, Transformation-related protein 63
| Host / Isotype: Rabbit / IgG | Class: Antibody |
| Reactivity: human, mouse, rat | Immunogen: tumor protein p63 |
| Applications: WB, IF/ICC, ELISA | Observed Molecular Weight: 68-75 kDa |
| Formulation: PBS, Azide, Glycerol | GenBank Accession Number: TP63 |
| Conjugate: Unconjugated | Gene Symbol: 8626 |
| Tested Applications: Positive WB detected in | Gene ID (NCBI): Unconjugated |
| Application: Western Blot (WB) | RRID: Liquid |
| Dilution: WB : 1:1000-1:6000 | Conjugate: Protein A purification |
| Tested Reactivity: Human, Mouse, Rat | Form: Q9H3D4-2 |
| Host / Isotype: Recombinant | Background Information: DeltaN p63 (ΔNp63) is a major protein isoform encoded by the TP63 gene. The TP63 gene is a member of the p53 gene family, which also includes p53 and p73. The key defining feature of DeltaN p63 (ΔNp63) is the absence of the full N-terminal transactivation domain. However, it retains the central DNA-binding domain (DBD) and the C-terminal oligomerization domain (OD). The α-isoform also has a sterile alpha motif (SAM) domain and a transcriptional inhibitory domain (TID). DeltaN p63 isoforms can act as dominant-negative inhibitors of p53 and TAp63 by competing for DNA binding sites or forming non-functional dimers. DeltaN p63 is highly expressed in basal layers of epithelial tissues and is essential for the maintenance and proliferation of epithelial stem cells. It plays a pivotal role in epidermal development, stratification, and regeneration. |
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