Anti-Human KLRB1/CD161 Rabbit Recombinant Antibody proteintech 98281-1-RR
$76.00
In stock
SKU
98281-1-RR
CD161, 242140H5, HNKR-P1a, hNKR P1A, C-type lectin domain family 5 member B
| Host / Isotype: Rabbit / IgG | Class: Antibody |
| Reactivity: human | Immunogen: killer cell lectin-like receptor subfamily B, member 1 |
| Applications: FC | Observed Molecular Weight: NM_002258.3 |
| Formulation: PBS, Azide | GenBank Accession Number: 3820 |
| Conjugate: Unconjugated | Gene Symbol: ENSG00000111796 |
| Tested Applications: Positive FC detected in | Gene ID (NCBI): Unconjugated |
| Application: Flow Cytometry (FC) | RRID: Liquid |
| Dilution: FC : 0.25 ug per 10^6 cells in 100 μl suspension | Conjugate: Protein A purfication |
| Tested Reactivity: Human | Form: Q12918 |
| Host / Isotype: Recombinant | Background Information: CD161, also known as KLRB1 or NKR-P1A, is a type II transmembrane C-type lectin-like receptor and is expressed on the cell membrane as disulfide-linked homodimer (PMID: 8077657). It is expressed by the majority of NK cells and subsets of peripheral T cells, including both CD4+ and CD8+ T cells, and is expressed preferentially on adult T cells with a "memory" antigenic phenotype (PMID: 8077657; 22566826). Expression of CD161 correlates with the cytotoxic function of CD16+ NK cells, and ligation of CD161 with its ligand LLT1 inhibits NK cell cytotoxicity and cytokine secretion (PMID: 29686665). |
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