Anti-Human CD155/PVR (SKII.4) Mouse IgG2a Recombinant Antibody proteintech 65632-1-MR
$123.00
In stock
SKU
65632-1-MR
PVR, CD155, HVED, Necl 5, NECL5
| Host / Isotype: Mouse / IgG2a | Class: Antibody |
| Reactivity: human | Immunogen: poliovirus receptor |
| Applications: FC | Observed Molecular Weight: BC015542 |
| Formulation: PBS, Azide | GenBank Accession Number: 5817 |
| Conjugate: Unconjugated | Gene Symbol: AB_3670370 |
| Tested Applications: Positive FC detected in | Gene ID (NCBI): Unconjugated |
| Application: Flow Cytometry (FC) | RRID: Liquid |
| Dilution: FC : 0.25 ug per 10^6 cells in 100 μl suspension | Conjugate: Protein A purification |
| Tested Reactivity: Human | Form: P15151 |
| Host / Isotype: Recombinant | Background Information: CD155, also known as PVR, is a type I transmembrane glycoprotein in the immunoglobulin superfamily. It contains three extracellular immunoglobulin-like domains, D1-D3, of which D1 is recognized by the virus. Mature human CD155 consists of a 323 amino acid extracellular domain with one N-terminal V-type and two C2-type Ig-like domains, a 24 amino acid transmembrane segment, and a 50 amino acid cytoplasmic tail. CD155 is thought to play a role in adhesion by interaction with the ECM component vitronectin as well as a role in NK killing of tumor cells. CD155 binds to two receptors of NK cells, CD96 and CD226, and accumulates at cell-cell contact sites, leading to the formation of mature immune synapses between NK cells and target cells. CD155 serves as the entry receptor for poliovirus and thereby mediates human susceptibility to poliovirus infection. |
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