Phospho-BCL2 (Ser70) Recombinant monoclonal antibody proteintech 80771-2-RR
$449.00
In stock
SKU
80771-2-RR
BCL-2, BCL2, 230061A8
| Host / Isotype: Rabbit / IgG | Class: Recombinant |
| Reactivity: human | Immunogen: Peptide Predict reactive species |
| Applications: WB, IHC, FC (Intra), ELISA | Observed Molecular Weight: 26 kDa |
| Formulation: PBS, Azide, Glycerol | GenBank Accession Number: BC027258 |
| Conjugate: Unconjugated | Gene Symbol: BCL2 |
| Tested Applications: Positive WB detected in | Gene ID (NCBI): 596 |
| Application: Western Blot (WB) | RRID: AB_3670487 |
| Dilution: WB : 1:2000-1:10000 | Conjugate: Unconjugated |
| Tested Reactivity: Human | Form: Liquid |
| Host / Isotype: Rabbit / IgG | Background Information: BCL2 belongs to the Bcl-2 family. The anti-apoptotic protein BCL2 can bind to the pro-apoptotic protein BAX or BAK1 to form heterodimers that modulate apoptosis. BCL2 phosphorylation at Ser70 enhances binding to BAX and BAD and is essential for its anti-apoptotic activity. Conversely, BCL2 also regulates autophagy via interaction with BECN1/Beclin 1; moreover, BCL2 phosphorylation including at Ser70 leads to its dissociation from BECN1 and induction of autophagy. These findings suggest that BCL2 regulates the balance between apoptosis and autophagy. (PMID: 29433359) |
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