GPR161 Polyclonal antibody proteintech 13398-1-AP
$449.00
In stock
SKU
13398-1-AP
G-protein coupled receptor 161, G-protein coupled receptor RE2
| Host / Isotype: Rabbit / IgG | Class: Polyclonal |
| Reactivity: Human, Mouse, Canine And More (4) | Immunogen: CatNo: Ag4221 Product name: Recombinant human GPR161 protein Source: e coli.-derived, PGEX-4T Tag: GST Domain: 321-529 aa of BC028163 Sequence: PLIYGLWNKTVRKELLGMCFGDRYYREPFVQRQRTSRLFSISNRITDLGLSPHLTALMAGGQPLGHSSSTGDTGFSCSQDSGTDMMLLEDYTSDDNPPSHCTCPPKRRSSVTFEDEVEQIKEAAKNSILHVKAEVHKSLDSYAASLAKAIEAEAKINLFGEEALPGVLVTARTVPGGGFGGRRGSRTLVSQRLQLQSIEEGDVLAAEQR Predict reactive species |
| Applications: WB, IF/ICC, IP, CoIP, ELISA | Observed Molecular Weight: 529 aa, 59 kDa |
| Formulation: PBS, Azide, Glycerol | GenBank Accession Number: BC028163 |
| Conjugate: Unconjugated | Gene Symbol: GPR161 |
| Tested Applications: Positive WB detected in | Gene ID (NCBI): 23432 |
| Application: Western Blot (WB) | RRID: AB_2113965 |
| Dilution: WB : 1:1000-1:8000 | Conjugate: Unconjugated |
| Tested Reactivity: Human, Mouse, Canine | Form: Liquid |
| Host / Isotype: Rabbit / IgG | Background Information: GPR161 (also known as RE2) is an orphan G protein-coupled receptor and plays an important role in the Hh pathway. In the absence of Hh signals, GPR161 localizes to primary cilia and keeps the downstream GLI transcription factors in their repressor forms (PMID: 26305592). Ciliary localization of GPR161 requires TULP3 and the IFT-A complex. In the presence of SHH, GPR161 is removed from primary cilia and is internalized into recycling endosomes, preventing its activity and allowing activation of the Shh signaling. GPR161 has a calculated molecular mass of 59 kDa. The 70-kDa band probably represents a modified version of GPR161 (PMID: 18250320). |
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