Anti-Human CXCL8/IL-8 Rabbit Recombinant Antibody proteintech 98137-1-RR
$59.00
In stock
SKU
98137-1-RR
CXCL8, IL8, IL-8, 240889B2, C X C motif chemokine 8
| Host / Isotype: Rabbit / IgG | Class: Antibody |
| Reactivity: human | Immunogen: interleukin 8 |
| Applications: FC (Intra) | Observed Molecular Weight: BC013615 |
| Formulation: PBS, Azide | GenBank Accession Number: 3576 |
| Conjugate: Unconjugated | Gene Symbol: ENSG00000169429 |
| Tested Applications: Positive FC (Intra) detected in | Gene ID (NCBI): AB_3672283 |
| Application: Flow Cytometry (FC) (INTRA) | RRID: Unconjugated |
| Dilution: FC (INTRA) : 0.25 ug per 10^6 cells in 100 μl suspension | Conjugate: Liquid |
| Tested Reactivity: Human | Form: Protein A purfication |
| Host / Isotype: Recombinant | Background Information: Interleukin 8 (IL-8), also known as CXCL8, is a CXC chemokine family member. This chemokine is secreted by a variety of cell types including monocyte/macrophages, T cells, neutrophils, fibroblasts, endothelial cells, and various tumor cell lines in response to inflammatory stimuli. IL-8 has two primary functions. It induces chemotaxis in target cells, primarily neutrophils but also other granulocytes, causing them to migrate toward the site of infection. IL-8 also induces phagocytosis once they have arrived. This gene is believed to play a role in the pathogenesis of bronchiolitis, a common respiratory tract disease caused by viral infection. IL-8 is also known to be a potent promoter of angiogenesis. IL-8 has been associated with tumor angiogenesis, metastasis, and poor prognosis in breast cancer. IL-8 may present a novel therapeutic target for estrogen driven breast carcinogenesis and tumor progression. |
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