LPXN Recombinant monoclonal antibody proteintech 83657-5-RR
$449.00
In stock
SKU
83657-5-RR
240483G10, LDLP, LDPL
| Host / Isotype: Rabbit / IgG | Class: Antibody |
| Reactivity: human | Immunogen: leupaxin |
| Applications: WB, IF/ICC, ELISA | Observed Molecular Weight: 45 kDa |
| Formulation: PBS, Azide, Glycerol | GenBank Accession Number: LPXN |
| Conjugate: Unconjugated | Gene Symbol: 9404 |
| Tested Applications: Positive WB detected in | Gene ID (NCBI): AB_3671265 |
| Application: Western Blot (WB) | RRID: Unconjugated |
| Dilution: WB : 1:5000-1:50000 | Conjugate: Liquid |
| Tested Reactivity: Human | Form: Protein A purfication |
| Host / Isotype: Recombinant | Background Information: LPXN, also known as Leupaxin, LDPL, belongs to the paxillin family. LPXN Contributes to the regulation of cell adhesion, spreading, and cell migration and acts as a negative regulator in integrin-mediated cell adhesion events (PMID: 20543562). LPXN has four leucine-rich LD-motifs in the N-terminus and four LIM domains in the C-terminus. It may function in cell type-specific signaling by associating with PYK2, a member of the focal adhesion kinase family (PMID: 9565592). Studies in breast cancer implicate LPXN is involved in the regulation of ER action as a co-factor (PMID: 25955236). LPXN is expressed in prostate cancer cells and its expression intensity is directly linked to PCa progression (PMID: 18451096). |
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