LAT Recombinant monoclonal antibody proteintech 82901-1-RR
$449.00
In stock
SKU
82901-1-RR
2P13, 36 kDa phosphotyrosine adapter protein, LAT1, Linker for activation of T-cells family member 1, p36 38
| Host / Isotype: Rabbit / IgG | Class: Antibody |
| Reactivity: human, mouse | Immunogen: linker for activation of T cells |
| Applications: WB, IF/ICC, FC (Intra), ELISA | Observed Molecular Weight: 36-38 kDa |
| Formulation: PBS, Azide, Glycerol | GenBank Accession Number: LAT |
| Conjugate: Unconjugated | Gene Symbol: 27040 |
| Tested Applications: Positive WB detected in | Gene ID (NCBI): AB_3670630 |
| Application: Western Blot (WB) | RRID: Unconjugated |
| Dilution: WB : 1:1000-1:5000 | Conjugate: Liquid |
| Tested Reactivity: Human, Mouse | Form: Protein A purification |
| Host / Isotype: Recombinant | Background Information: LAT is a membrane-localized adaptor protein which is primarily concentrated in microdomains by palmitoylation. LAT plays a central role in T-cell activation by nucleating signaling complexes that are critical for the propagation of T-cell signals from the plasma membrane to the cellular interior. In addition to being a positive regulator of T cell signaling, LAT also recruits several negative regulatory proteins, including kinases, phosphatases, and ubiquitin ligases, which ultimately leads to signal termination. LAT is subject to ubiquitylation, and ubiquitin-resistant mutants of LAT display enhanced signaling. |
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