IRF3 Recombinant monoclonal antibody proteintech 80519-1-RR
$449.00
In stock
SKU
80519-1-RR
2H6, interferon regulatory factor 3, IRF 3, IRF-3
| Host / Isotype: Rabbit / IgG | Class: Recombinant |
| Reactivity: human, mouse, rat, zebrafish | Immunogen: Peptide Predict reactive species |
| Applications: WB, IHC, IF/ICC, ELISA | Observed Molecular Weight: 47 kDa |
| Formulation: PBS, Azide, Glycerol | GenBank Accession Number: BC009395 |
| Conjugate: Unconjugated | Gene Symbol: IRF3 |
| Tested Applications: Positive WB detected in | Gene ID (NCBI): 3661 |
| Application: Western Blot (WB) | RRID: AB_2918899 |
| Dilution: WB : 1:2000-1:10000 | Conjugate: Unconjugated |
| Tested Reactivity: Human, Mouse, Rat, Zebrafish | Form: Liquid |
| Host / Isotype: Rabbit / IgG | Background Information: The virul-induced expression of interferon(IFN) genes in infected cells implicate in the interplay of several constitutively expressed and virus-activated transcription factors. A family of IFN regulatory factors(IRFs) have been shown to has a role in the transcription of IFN genes as well as IFN-stimulated genes. IRF3 is a novel key transcriptional regulator of type I IFN-dependent immune responses and involves in the innate immune response against DNA and RNA viruses, by binding to the promoters of IFN. It located in the cytoplasm of uninfected cells in an inactive form, and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, could be phosphorylated by IKBKE and TBK1 kinases. This induces a conformational change, leading to its dimerization, nuclear localization and association with CREB binding protein (CREBBP) to form dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of the type I IFN and ISG genes. |
Reviews
Write Your Own Review
Related Products
Check items to add to the cart or
