HER2/ErbB2 Recombinant monoclonal antibody proteintech 84046-1-RR
$449.00
In stock
SKU
84046-1-RR
ERBB2, 240802C2, CD340, HER 2, HER 2/neu
| Host / Isotype: Rabbit / IgG | Class: Antibody |
| Reactivity: human, mouse | Immunogen: v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) |
| Applications: WB, IHC, IF/ICC, ELISA | Observed Molecular Weight: 185 kDa |
| Formulation: PBS, Azide, Glycerol | GenBank Accession Number: HER2/ErbB2 |
| Conjugate: Unconjugated | Gene Symbol: 2064 |
| Tested Applications: Positive WB detected in | Gene ID (NCBI): AB_3671613 |
| Application: Western Blot (WB) | RRID: Unconjugated |
| Dilution: WB : 1:2000-1:10000 | Conjugate: Liquid |
| Tested Reactivity: Human, Mouse | Form: Protein A purfication |
| Host / Isotype: Recombinant | Background Information: HER2, also known as ErbB2 and Neu, is a 185-kDa transmembrane glycoprotein member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. It has no ligand-binding domain and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signaling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Amplification and overexpression of HER2 have been reported in numerous cancers, including breast and ovarian tumors. HER2 is a therapeutic target for the treatment of breast cancer and other carcinomas. |
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