Phospho-GSK3B (Ser389) Polyclonal antibody proteintech 14850-1-AP
$449.00
In stock
SKU
14850-1-AP
GSK3B (Ser389), GSK3β (Ser389), GSK-3β (Ser389), p-GSK 3β (Ser389), p-GSK3B
| Host / Isotype: Rabbit / IgG | Class: Polyclonal |
| Reactivity: Mouse, Rat And More (2) | Immunogen: Peptide Predict reactive species |
| Applications: WB, IF, ELISA | Observed Molecular Weight: 48 kDa |
| Formulation: PBS, Azide, Glycerol | GenBank Accession Number: BC060743 |
| Conjugate: Unconjugated | Gene Symbol: Gsk3b |
| Tested Applications: Positive WB detected in | Gene ID (NCBI): 56637 |
| Application: Western Blot (WB) | RRID: AB_2878085 |
| Dilution: WB : 1:1000-1:4000 | Conjugate: Unconjugated |
| Tested Reactivity: Mouse, Rat | Form: Liquid |
| Host / Isotype: Rabbit / IgG | Background Information: Glycogen synthase kinase 3s are serine/threonine kinases that were originally identified as key regulatory enzymes in glucose metabolism. There are two isoforms, GSK3α and GSK3β, encoded by separate genes, which are overall 85% homologous to each other, with 95% identity in the kinase domains. To date, phosphorylation at Ser9 by Akt is the best-characterized mechanism for the inhibition of GSK3β activity. GSK3β is phosphorylated at S389 in vivo by p38 MAPK and that this alternative regulatory mechanism of GSK3β is tissue-specific(PMID:18451303). |
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