HEC1/HEC/NDC80 Recombinant monoclonal antibody proteintech 83859-1-RR
$449.00
In stock
SKU
83859-1-RR
NDC80, 5A2, HEC, HEC1, HsHec1
| Host / Isotype: Rabbit / IgG | Class: Antibody |
| Reactivity: human | Immunogen: NDC80 homolog, kinetochore complex component (S. cerevisiae) |
| Applications: WB, IF/ICC, FC (Intra), ELISA | Observed Molecular Weight: 74 kDa |
| Formulation: PBS, Azide, Glycerol | GenBank Accession Number: NDC80 |
| Conjugate: Unconjugated | Gene Symbol: 10403 |
| Tested Applications: Positive WB detected in | Gene ID (NCBI): AB_3671443 |
| Application: Western Blot (WB) | RRID: Unconjugated |
| Dilution: WB : 1:2000-1:10000 | Conjugate: Liquid |
| Tested Reactivity: Human | Form: Protein A purfication |
| Host / Isotype: Recombinant | Background Information: NDC80 complex is a heterotetrameric protein complex comprised of Hec1 (also called Ndc80), Nuf2, Spc24, and Spc25. Mis12 complex (bound to CENP-C or CENP-T) or CDK1-phosphorylated CENP-T to anchor the NDC80 complex to the kinetochore. HEC is one of several proteins involved in spindle checkpoint signaling. This surveillance mechanism assures correct segregation of chromosomes during cell division by detecting unaligned chromosomes and causing prometaphase arrest until the proper bipolar attachment of chromosomes is achieved. |
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