IGF1R/CD221 Monoclonal antibody proteintech 66283-1-Ig
$449.00
In stock
SKU
66283-1-Ig
IGF 1 receptor, IGF1R, IGF-I receptor, IGFIR, IGFR
| Host / Isotype: Mouse / IgG1 | Class: Monoclonal |
| Reactivity: Human, Rat And More (1) | Immunogen: Peptide Predict reactive species |
| Applications: WB, IHC, ELISA | Observed Molecular Weight: 155 kDa |
| Formulation: PBS, Azide, Glycerol | GenBank Accession Number: NM_000875 |
| Conjugate: Unconjugated | Gene Symbol: IGF1R |
| Tested Applications: Positive WB detected in | Gene ID (NCBI): 3480 |
| Application: Western Blot (WB) | RRID: AB_2881666 |
| Dilution: WB : 1:1000-1:8000 | Conjugate: Unconjugated |
| Tested Reactivity: Human, Rat | Form: Liquid |
| Host / Isotype: Mouse / IgG1 | Background Information: IGF1R, also named as CD221, is a receptor tyrosine kinase which mediates actions of INS-like growth factor 1 (IGF1). IGF1R binds IGF1 with high affinity and IGF2 and INS with a lower affinity, the activated IGF1R is involved in cell growth and survival control. It is crucial for tumor transformation and survival of malignant cells. IGF1R is translated as ~220?kDa pro-receptors (PMID: 33969359). IGF1R is a heterotetrameric receptor, composed of two alpha subunits (~130 kDa) and two beta subunits (~100-120 kDa) (PMID: 6279656). Both the alpha and beta subunits are synthesized from a single mRNA precursor. The precursor is then glycosylated, proteolytically cleaved, and crosslinked by cysteine bonds. |
Reviews
Write Your Own Review
Related Products
Check items to add to the cart or
