HER2/ErbB2 Polyclonal antibody proteintech 18299-1-AP
$449.00
In stock
SKU
18299-1-AP
ERBB2, CD340, HER 2, HER 2/neu, HER2
| Host / Isotype: Rabbit / IgG | Class: Polyclonal |
| Reactivity: Human, Mouse And More (2) | Immunogen: Peptide Predict reactive species |
| Applications: WB, IHC, IF-Fro, IP, ELISA | Observed Molecular Weight: 138 kDa |
| Formulation: PBS, Azide, Glycerol | GenBank Accession Number: BC167147 |
| Conjugate: Unconjugated | Gene Symbol: HER2/ErbB2 |
| Tested Applications: Positive WB detected in | Gene ID (NCBI): 2064 |
| Application: Western Blot (WB) | RRID: AB_2099264 |
| Dilution: WB : 1:2000-1:12000 | Conjugate: Unconjugated |
| Tested Reactivity: Human, Mouse | Form: Liquid |
| Host / Isotype: Rabbit / IgG | Background Information: HER2, also known as ErbB2 and Neu, is a 185-kDa transmembrane glycoprotein that is a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. It has no ligand-binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Amplification and/or overexpression of HER2 have been reported in numerous cancers, including breast and ovarian tumors. HER2 is a therapeutic target for the treatment of breast cancer and other carcinomas. This antibody raised against a synthesized peptide corresponding to 1237-1255aa of human HER2 recognizes the 185-kDa full-length glycosylated form and other lower molecular-mass forms of HER2, including the truncated form. |
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