Angiopoietin-2 Recombinant monoclonal antibody proteintech 83816-1-RR
$449.00
In stock
SKU
83816-1-RR
Angpt2, angiopoietin 2, Ang2, Ang 2, Agpt2
| Host / Isotype: Rabbit / IgG | Class: Recombinant |
| Reactivity: mouse | Immunogen: Recombinant protein Predict reactive species |
| Applications: WB, IHC, IP, ELISA | Observed Molecular Weight: 56KD |
| Formulation: PBS, Azide, Glycerol | GenBank Accession Number: NM_007426.4 |
| Conjugate: Unconjugated | Gene Symbol: Angpt2 |
| Tested Applications: Positive WB detected in | Gene ID (NCBI): 11601 |
| Application: Western Blot (WB) | RRID: AB_3671402 |
| Dilution: WB : 1:2000-1:10000 | Conjugate: Unconjugated |
| Tested Reactivity: Mouse | Form: Liquid |
| Host / Isotype: Rabbit / IgG | Background Information: Angiopoietin-2 (ANGPT2, ANG-2) is as a regulator of vessel enlargement, and ANGPT2 inhibition prevented pathological vessel enlargement (PMID: 34758631). ANGPT2 destabilizes vessels and promotes angiogenesis through antagonism of ANGPT1 (PMID: 34758631). Ang2 was initially identified by homology with Ang1 and is expressed predominantly by endothelial cells, where it is stored in intracellular secretory granules called Weibel-Palade bodies (WPB) and promptly released after endothelium activation. Like Ang1, Ang2 binds to Tie2 receptor, but with different pathophysiological effects. While Ang1 fosters endothelial stabilization, Ang2 can antagonize Ang1, blocking Tie2 activation and leading to vessel destabilization (PMID: 31756341). |
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