PPP1R15B Recombinant monoclonal antibody proteintech 83016-6-RR
$449.00
In stock
SKU
83016-6-RR
PPP1R15B;CReP, 240052G5, CREP, FLJ14744
| Host / Isotype: Rabbit / IgG | Class: Antibody |
| Reactivity: human | Immunogen: protein phosphatase 1, regulatory (inhibitor) subunit 15B |
| Applications: WB, IF/ICC, FC (Intra), ELISA | Observed Molecular Weight: 100-110 kDa |
| Formulation: PBS, Azide, Glycerol | GenBank Accession Number: PPP1R15B |
| Conjugate: Unconjugated | Gene Symbol: 84919 |
| Tested Applications: Positive WB detected in | Gene ID (NCBI): AB_3670758 |
| Application: Western Blot (WB) | RRID: Unconjugated |
| Dilution: WB : 1:5000-1:50000 | Conjugate: Liquid |
| Tested Reactivity: Human | Form: Protein A purfication |
| Host / Isotype: Recombinant | Background Information: Protein phosphatase 1 regulatory subunit 15B(PPP1R15B) is a member of PPP1R15 family, it forms a complex with protein phosphatase1(PP1) and NCK1/2, maintaining low levels of EIF2S1 phosphorylation in unstressed cells, thus is also named constitutive repressor of eIF2alpha phosphorylation (CReP). PPP1R15B is assoicated in endoplasmic reticulum (ER) stress response resulting to a role in translation regulation. Knock-down of PPP1R15B strongly protected mammalian cells against oxidative stress, peroxynitrite stress, and more modestly against accumulation of malfolded proteins in the ER. Recently, PPP1R15B was found to associate with cell membranes and regulate membrane traffic in a PP1c-independent manner, suggesting a novel link between translation and traffic. MW of PPP1R15B is 80 kDa. Observed MW of PPP1R15B is from 100-110 kDa maybe due to phosphorylation (PMID: 28492545). |
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