Phospho-mTOR (Ser2448) Recombinant monoclonal antibody proteintech 80596-1-RR
$449.00
In stock
SKU
80596-1-RR
mTOR (Ser2448), p mTOR , p mTOR (Ser2448), p mTOR Ser2448, Phospho mTOR
| Host / Isotype: Rabbit / IgG | Class: Recombinant |
| Reactivity: Human, Mouse, Rat And More (1) | Immunogen: Peptide Predict reactive species |
| Applications: WB, IHC, IF, FC (Intra), ELISA | Observed Molecular Weight: 289 kDa |
| Formulation: PBS, Azide, Glycerol | GenBank Accession Number: BC117166 |
| Conjugate: Unconjugated | Gene Symbol: mTOR |
| Tested Applications: Positive WB detected in | Gene ID (NCBI): 2475 |
| Application: Western Blot (WB) | RRID: AB_2918905 |
| Dilution: WB : 1:5000-1:50000 | Conjugate: Unconjugated |
| Tested Reactivity: Human, Mouse, Rat | Form: Liquid |
| Host / Isotype: Rabbit / IgG | Background Information: MTOR, also named as FRAP1, FRAP, FRAP2 and RAPT1, belongs to the PI3/PI4-kinase family. MTOR is a Ser/Thr protein kinase that functions as an ATP and amino acid sensor to balance nutrient availability and cell growth. MTOR is kinase subunit of both mTORC1 and mTORC2, which regulate cell growth and survival in response to nutrient and hormonal signals. mTORC1 is activated in response to growth factors or amino-acids. mTORC2 is also activated by growth factors, but seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTOR is phosphorylated at Ser2448 via the PI3 kinase/Akt signaling pathway and autophosphorylated at Ser2481. mTOR plays a key role in cell growth and homeostasis and may be abnormally regulated in tumors. |
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