YBX1 Polyclonal antibody proteintech 20339-1-AP
$449.00
In stock
SKU
20339-1-AP
CBF A, CBF-A, CCAAT-binding transcription factor I subunit A, DBPB, DNA-binding protein B
| Host / Isotype: Rabbit / IgG | Class: Polyclonal |
| Reactivity: Human, Mouse, Rat And More (1) | Immunogen: CatNo: Ag14129 Product name: Recombinant human YBX1 protein Source: e coli.-derived, PGEX-4T Tag: GST Domain: 134-303 aa of BC010430 Sequence: QGSKYAADRNHYRRYPRRRGPPRNYQQNYQNSESGEKNEGSESAPEGQAQQRRPYRRRRFPPYYMRRPYGRRPQYSNPPVQGEVMEGADNQGAGEQGRPVRQNMYRGYRPRFRRGPPRQRQPREDGNEEDKENQGDETQGQQPPQRRYRRNFNYRRRRPENPKPQDGKET Predict reactive species |
| Applications: WB, IHC, IF/ICC, IP, CoIP, ChIP, RIP, ELISA | Observed Molecular Weight: 324 aa, 36 kDa |
| Formulation: PBS, Azide, Glycerol | GenBank Accession Number: BC010430 |
| Conjugate: Unconjugated | Gene Symbol: YBX1 |
| Tested Applications: Positive WB detected in | Gene ID (NCBI): 4904 |
| Application: Western Blot (WB) | RRID: AB_10665424 |
| Dilution: WB : 1:5000-1:50000 | Conjugate: Unconjugated |
| Tested Reactivity: Human, Mouse, Rat | Form: Liquid |
| Host / Isotype: Rabbit / IgG | Background Information: Y box binding protein 1(YBX1) is one of cis-acting elements which has a role in regulation of the expression of HLA class II genes. YBX1 is great of importance in regulation of PTP1B expression. It can bind to splice sites mediate pre-mRNA alternative splicing regulation. Also, it involves the regulation of translation by modulation of the interaction between the mRNA and eukaryotic initiation factors. Its transcriptional activity on the multidrug resistance gene MDR1 is enhanced in presence of the APEX1 acetylated form at 'Lys-6' and 'Lys-7'. The secreted form acts as an extracellular mitogen and stimulates cell migration and proliferation. The calculated molecular weight of YBX1 is 36 kDa, but modified YBX1 is about 36-56 kDa (PMID: 27384875 ). Recently, researchers developed a biomimetic nanoplatform to deliver RNA piR-RCC specifically into RCC tumors. This RNA interacts with YBX1 to inhibit tumor proliferation and metastasis (PMID: 40411401). |
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