PELP1 Monoclonal antibody proteintech 67050-1-Ig
$449.00
In stock
SKU
67050-1-Ig
1B11E4, HMX3, MNAR, Modulator of non-genomic activity of estrogen receptor, Proline-, glutamic acid- and leucine-rich protein 1
| Host / Isotype: Mouse / IgG2b | Class: Monoclonal |
| Reactivity: Human And More (1) | Immunogen: CatNo: Ag25729 Product name: Recombinant human PELP1 protein Source: e coli.-derived, PET28a Tag: 6*His Domain: 39-338 aa of BC069058 Sequence: ESVSGLLQPRTGSAVAPVHPPNRSAPHLPGLMCLLRLHGSVGGAQNLSALGALVSLSNARLSSIKTRFEGLCLLSLLVGESPTELFQQHCVSWLRSIQQVLQTQDPPATMELAVAVLRDLLRYAAQLPALFRDISMNHLPGLLTSLLGLRPECEQSALEGMKACMTYFPRACGSLKGKLASFFLSRVDALSPQLQQLACECYSRLPSLGAGFSQGLKHTESWEQELHSLLASLHTLLGALYEGAETAPVQNEGPGVEMLLSSEDGDAHVLLQLRQRFSGLARCLGLMLSSEFGAPVSVPV Predict reactive species |
| Applications: WB, IHC, IF-P, IF-Fro, FC (Intra), ELISA | Observed Molecular Weight: 1130 aa, 120 kDa |
| Formulation: PBS, Azide, Glycerol | GenBank Accession Number: BC069058 |
| Conjugate: Unconjugated | Gene Symbol: PELP1 |
| Tested Applications: Positive WB detected in | Gene ID (NCBI): 27043 |
| Application: Western Blot (WB) | RRID: AB_2882363 |
| Dilution: WB : 1:2000-1:8000 | Conjugate: Unconjugated |
| Tested Reactivity: Human | Form: Liquid |
| Host / Isotype: Mouse / IgG2b | Background Information: PELP1 was first identified as a 160 kDa protein in a screen for Src homology 2 (SH2) domain-binding proteins. PELP1 is overexpressed in 60-80% of breast tumors and plays important roles in both ER genomic and non-genomic signaling. In vivo, PELP1 subcellular localization is primarily nuclear in normal breast tissue, but it is localized to the cytoplasm in about 40% of invasive breast tumors. In the nucleus, PELP1 interacts with a number of transcription factors. The proto-oncogenic functions of PELP1 involve different cellular processes including epigenetic modifications leading to ER transactivation and breast cancer progression. Furthermore, PELP1 activates kinase cascades in the cytoplasm such as MAPK activation via c-Src and PI3K signaling. |
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