PAX8 Polyclonal antibody proteintech 10336-1-AP
$449.00
In stock
SKU
10336-1-AP
PAX-8, paired box 8, Paired box protein Pax 8, Paired box protein Pax-8, PAX 8
| Host / Isotype: Rabbit / IgG | Class: Polyclonal |
| Reactivity: Human, Mouse And More (5) | Immunogen: Recombinant protein Predict reactive species |
| Applications: WB, IHC, IF/ICC, IF-P, IP, CoIP, ELISA | Observed Molecular Weight: 48 kDa |
| Formulation: PBS, Azide, Glycerol | GenBank Accession Number: BC001060 |
| Conjugate: Unconjugated | Gene Symbol: PAX8 |
| Tested Applications: Positive WB detected in | Gene ID (NCBI): 7849 |
| Application: Western Blot (WB) | RRID: AB_2236705 |
| Dilution: WB : 1:2000-1:10000 | Conjugate: Unconjugated |
| Tested Reactivity: Human, Mouse | Form: Liquid |
| Host / Isotype: Rabbit / IgG | Background Information: PAX8 is a member of the paired box (PAX) family of transcription factors, typically containing a paired box domain and a paired-type homeodomain. It is expressed during organogenesis of the thyroid gland, kidney and Mullerian system. It is thought to regulate the expression of Wilms tumor suppressor (WT1) gene and mutations in PAX8 have been associated with Wilms tumor cells, thyroid and ovarian carcinomas. PAX8 is a useful marker in distinguishing ovarian carcinomas from mammary carcinomas (PMID: 18724243). PAX8 is expressed in a high percentage of ovarian serous, endometrioid, and clear cell carcinomas, but only rarely in primary ovarian mucinous adenocarcinomas. This antibody can detect all 5 isoforms of PAX8 (31 kDa, 34 kDa, 41 kDa, 43 kDa and 48 kDa). A 58-60 kDa form has also been reported (PMID:15650356, 1049952). |
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