IFITM2 Polyclonal antibody proteintech 12769-1-AP
$449.00
In stock
SKU
12769-1-AP
1 8D, 18D, DSPA2c, IFITM 2, Interferon-induced transmembrane protein 2
| Host / Isotype: Rabbit / IgG | Class: Polyclonal |
| Reactivity: Human, Mouse And More (1) | Immunogen: CatNo: Ag3451 Product name: Recombinant human IFITM2 protein Source: e coli.-derived, PGEX-4T Tag: GST Domain: 1-132 aa of BC009696 Sequence: MNHIVQTFSPVNSGQPPNYEMLKEEQEVAMLGAPHNPAPPTSTVIHIRSETSVPDHVVWSLFNTLFMNTCCLGFIAFAYSVKSRDRKMVGDVTGAQAYASTAKCLNIWALILGIFMTILLVIIPVLVVQAQR Predict reactive species |
| Applications: WB, IHC, IF/ICC, IP, ELISA | Observed Molecular Weight: 132 aa, 15 kDa |
| Formulation: PBS, Azide, Glycerol | GenBank Accession Number: BC009696 |
| Conjugate: Unconjugated | Gene Symbol: IFITM2 |
| Tested Applications: Positive WB detected in | Gene ID (NCBI): 10581 |
| Application: Western Blot (WB) | RRID: AB_2122089 |
| Dilution: WB : 1:2000-1:10000 | Conjugate: Unconjugated |
| Tested Reactivity: Human, Mouse | Form: Liquid |
| Host / Isotype: Rabbit / IgG | Background Information: IFITM2, also named as 1-8D, belongs to the CD225 family. It is an IFN-induced antiviral protein that mediates cellular innate immunity to at least three major human pathogens, namely influenza A H1N1 virus, West Nile virus (WNV), and dengue virus , by inhibiting the early steps of replication. IFITM2 induces cell cycle arrest and mediates apoptosis by caspase activation and in p53-independent manner. It is overexpressed in colon carcinoma. IFITM2 is a novel pro-apoptotic gene that will provide new insights into the regulated cellular pathways to death. IFITM proteins are recently identified as viral restriction factors that inhibit infection mediated by the influenza A virus (IAV) hemagglutinin (HA) protein. Also they serve as important components of the innate immune system to restrict HIV-1 infection. Catalog#12769-1-AP is a rabbit polyclonal antibody produced with full-length of human IFITM2. |
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