Anti-Human IFN-gamma Rabbit Recombinant Antibody proteintech 98187-1-RR
$60.00
In stock
SKU
98187-1-RR
IFNG, 241390B10, IFG, IFN gamma, IFN γ
| Host / Isotype: Rabbit / IgG | Class: Antibody |
| Reactivity: human | Immunogen: IFN gamma |
| Applications: FC (Intra) | Observed Molecular Weight: BC070256 |
| Formulation: PBS, Azide | GenBank Accession Number: 3458 |
| Conjugate: Unconjugated | Gene Symbol: ENSG00000111537 |
| Tested Applications: Positive FC (Intra) detected in | Gene ID (NCBI): AB_3672327 |
| Application: Flow Cytometry (FC) (INTRA) | RRID: Unconjugated |
| Dilution: FC (INTRA) : 0.25 ug per 10^6 cells in a 100 ?l suspension | Conjugate: Liquid |
| Tested Reactivity: Human | Form: Protein A purfication |
| Host / Isotype: Recombinant | Background Information: Interferon gamma (IFN γ), is a type II interferon that provides immunity against bacterial, viral and protozoan infections. In its active form, IFN γ is a glycosylated, non-covalently linked homodimer of 29-32 kDa subunits. It is produced by a number of immune cell types including natural killer cells, natural killer T cells, and effector lymphocyte T cells following antigenic and inflammatory triggers. The IFN γ dimer binds to its cognate receptor which has two subunits: IFN-γR1 which is the ligand-binding chain (α chain) and IFN-γR2, the signal-transducing chain (β chain). Binding to the receptor activates the JAK/STAT pathway which in turn activates IFN γ responsive genes. While IFN γ can inhibit viral replication, it also works as an immune-modulator and immune-stimulator by increasing surface expression of class I MHC proteins. (PMID: 19268625; 10688427) |
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