Anti-Human EMR2/CD312 Rabbit Recombinant Antibody proteintech 98260-1-RR
$183.00
In stock
SKU
98260-1-RR
EMR2, EGF-like module receptor 2, EGF like module receptor 2, CD312, Adhesion G protein-coupled receptor E2
| Host / Isotype: Rabbit / IgG | Class: Antibody |
| Reactivity: human | Immunogen: egf-like module containing, mucin-like, hormone receptor-like 2 |
| Applications: FC | Observed Molecular Weight: NM_013447.3 |
| Formulation: PBS, Azide | GenBank Accession Number: 30817 |
| Conjugate: Unconjugated | Gene Symbol: Unconjugated |
| Tested Applications: Positive FC detected in | Gene ID (NCBI): Liquid |
| Application: Flow Cytometry (FC) | RRID: Protein A purfication |
| Dilution: FC : 0.13 ug per 10^6 cells in 100 μl suspension | Conjugate: Q9UHX3-1 |
| Tested Reactivity: Human | Form: PBS with 0.09% sodium azide, pH 7.3. |
| Host / Isotype: Recombinant | Background Information: EMR2 (Epidermal Growth Factor-like module-containing Mucin-like Hormone Receptor 2), also known as CD312 or ADGRE2, is a member of the adhesion-GPCR family that contains extracellular EGF-like domains. EMR2 contains a total of five tandem EGF-like domains and expresses similar protein isoforms consisting of various numbers of EGF-like domains as a result of alternative RNA splicing (PMID: 10903844). EMR2 is restricted to myeloid cells including monocytes, macrophages, dendritic cells and granulocytes28 and its expression is highly regulated during monocyte/macrophage differentiation (PMID: 31969668).The ligation of EMR2 could increase neutrophil adhesion, migration and anti-microbial mediator production and could enhance the systemic inflammation (PMID: 27905560). |
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