Phospho-IRF3 (Ser396) Polyclonal antibody proteintech 29528-1-AP
$449.00
In stock
SKU
29528-1-AP
| Host / Isotype: Rabbit / IgG | Class: Polyclonal |
| Reactivity: Human And More (4) | Immunogen: Peptide Predict reactive species |
| Applications: WB, IHC, ELISA | Observed Molecular Weight: 47 kDa |
| Formulation: PBS, Azide, Glycerol | GenBank Accession Number: BC009395 |
| Conjugate: Unconjugated | Gene Symbol: IRF3 |
| Tested Applications: Positive WB detected in | Gene ID (NCBI): 3661 |
| Application: Western Blot (WB) | RRID: AB_2935415 |
| Dilution: WB : 1:1000-1:4000 | Conjugate: Unconjugated |
| Tested Reactivity: Human | Form: Liquid |
| Host / Isotype: Rabbit / IgG | Background Information: Interferons (IFNs) are a large family of multifunctional secreted proteins involved in antiviral defense, cell growth regulation, and immune activation(PMID: 18440553). A family of IFN regulatory factors(IRFs) have been shown to has a role in the transcription of IFN genes as well as IFN-stimulated genes. IRF3 is a novel key transcriptional regulator of type I IFN-dependent immune responses and involves in the innate immune response against DNA and RNA viruses, by binding to the promoters of IFN. IRF-3 is activated through phosphorylation by the kinases IKK? and/or TBK1. Phosphorylation at Ser396 is essential for IRF-3 activation. After cytoplasmic IRF-3 is phosphorylated at Ser386 and Ser396, phosphorylated IRF-3 translocates into the nucleus. This phosphorylated IRF-3 activates IFN and IFN-responsive genes. |
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