Anti-Human CD45RO (UCHL1) Mouse IgG2a Recombinant Antibody proteintech 65613-1-MR
$59.00
In stock
SKU
65613-1-MR
CD45, EC:3.1.3.48, GP180, L CA, LCA
| Host / Isotype: Mouse / IgG2a | Class: Antibody |
| Reactivity: human | Immunogen: protein tyrosine phosphatase, receptor type, C |
| Applications: IHC, FC | Observed Molecular Weight: CD45 |
| Formulation: PBS, Azide | GenBank Accession Number: ENSG00000081237 |
| Conjugate: Unconjugated | Gene Symbol: AB_3670360 |
| Tested Applications: Positive IHC detected in | Gene ID (NCBI): Unconjugated |
| Application: Immunohistochemistry (IHC) | RRID: Liquid |
| Dilution: IHC : 1:600-1:2400 | Conjugate: Protein A purification |
| Tested Reactivity: Human | Form: P08575 |
| Host / Isotype: Recombinant | Background Information: CD45, also known as protein tyrosine phosphatase, receptor type C, is a type I transmembrane protein expressed on the surface of all haematopoietic cells with the exception of erythrocytes and platelets (PMID: 3489673; 28615666). CD45 is a pan-haematopoietic cell marker and has been shown to be essential for T- and B-cell activation and signalling (PMID: 9429890; 16378097). CD45 exists as multiple isoforms due to alternative splicing of three exons (4, 5, and 6, designated A, B, and C) in the extracellular domain (PMID: 12414720). CD45RO is the shortest CD45 isoform (lacking all three exons) and is expressed by activated and memory T cells, thymocytes, some B cells, and weakly on granulocytes and macrophage (PMID: 27100180; 12414720). |
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