Anti-Human CD107a / LAMP1 (H4A3) Mouse IgG2a Recombinant Antibody proteintech 65596-1-MR
$68.00
In stock
SKU
65596-1-MR
CD107a, LAMP1, CD107 antigen-like family member A, CD107a/LAMP1, H4A3
| Host / Isotype: Mouse / IgG2a | Class: Antibody |
| Reactivity: human | Immunogen: lysosomal-associated membrane protein 1 |
| Applications: IF/ICC, FC, FC (Intra) | Observed Molecular Weight: BC006345 |
| Formulation: PBS, Azide | GenBank Accession Number: 3916 |
| Conjugate: Unconjugated | Gene Symbol: ENSG00000185896 |
| Tested Applications: Positive IF/ICC detected in | Gene ID (NCBI): AB_3670344 |
| Application: Immunofluorescence (IF)/ICC | RRID: Unconjugated |
| Dilution: IF/ICC : 1:250-1:1000 | Conjugate: Liquid |
| Tested Reactivity: Human | Form: Protein A purification |
| Host / Isotype: Recombinant | Background Information: LAMP1 (CD107a) is a heavily glycosylated membrane protein enriched in the lysosomal membrane. LAMP1 is extensively glycosylated with asparagine-linked oligosaccharides which protect it from intracellular proteolysis (PMID: 10521503). Although LAMP1 is expressed largely in the endosome-lysosomal membrane of cells, it is also found on the plasma membrane (PMID: 16168398). Elevated LAMP1 expression at the cell surface has also been detected during platelet and granulocytic cell activation, as well as in some tumor cells (PMID: 29085473). LAMP1 functions to provide selectins with carbohydrate ligands. This protein has also been shown to be a marker of degranulation on lymphocytes such as CD8+ and NK cells and may also play a role in tumor cell differentiation and metastasis (PMID: 18835598; 29085473; 9426697). |
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