AMACR/p504S Recombinant monoclonal antibody proteintech 84891-2-RR
$449.00
In stock
SKU
84891-2-RR
AMACR, p504S, 242456D1, 2-methylacyl-CoA racemase, Alpha-methylacyl-CoA racemase
| Host / Isotype: Rabbit / IgG | Class: Antibody |
| Reactivity: human | Immunogen: alpha-methylacyl-CoA racemase |
| Applications: WB, IHC, ELISA | Observed Molecular Weight: 42 kDa |
| Formulation: PBS, Azide, Glycerol | GenBank Accession Number: AMACR |
| Conjugate: Unconjugated | Gene Symbol: 23600 |
| Tested Applications: Positive WB detected in | Gene ID (NCBI): Unconjugated |
| Application: Western Blot (WB) | RRID: Liquid |
| Dilution: WB : 1:5000-1:50000 | Conjugate: Protein A purification |
| Tested Reactivity: Human | Form: Q9UHK6 |
| Host / Isotype: Recombinant | Background Information: AMACR(Alpha-methyl acyl-CoA racemase) belongs to the CaiB/BaiF CoA-transferase family. A mitochondrial and peroxisomal enzyme catalyzes the conversion of 2R stereoisomers of phytanic and pristanic acid to their S counterparts. AMACR has previously been shown to be a highly sensitive marker for colorectal and clinically localized prostate cancer (PCa). However, AMACR expression is down-regulated at the transcript and protein level in hormone-refractory metastatic PCa, suggesting a hormone-dependent expression of AMACR(PMID:12213712). It has 3 isoforms produced by alternative splicing and can form a dimer of 70-75 kDa(PMID:21812041). Defects in AMACR cause alpha-methyl acyl-CoA racemase deficiency (AMACRD) and congenital bile acid synthesis defect type 4 (CBAS4). |
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