ACSL1 Recombinant monoclonal antibody proteintech 87427-1-RR
$449.00
In stock
SKU
87427-1-RR
ACS1, Acyl CoA synthetase 1, Acyl-CoA synthetase 1, Arachidonate--CoA ligase, EC:6.2.1.15
| Host / Isotype: Rabbit / IgG | Class: Antibody |
| Reactivity: human, mouse, rat | Immunogen: acyl-CoA synthetase long-chain family member 1 |
| Applications: WB, ELISA | Observed Molecular Weight: 70-75 kDa |
| Formulation: PBS, Azide, Glycerol | GenBank Accession Number: ACSL1 |
| Conjugate: Unconjugated | Gene Symbol: 2180 |
| Tested Applications: Positive WB detected in | Gene ID (NCBI): Unconjugated |
| Application: Western Blot (WB) | RRID: Liquid |
| Dilution: WB : 1:5000-1:50000 | Conjugate: Protein A purification |
| Tested Reactivity: Human, Mouse, Rat | Form: P33121 |
| Host / Isotype: Recombinant | Background Information: ACSL1(Long-chain-fatty-acid--CoA ligase 1) is also named as FACL1, FACL2, LACS, LACS1, LACS2 and belongs to the ATP-dependent AMP-binding enzyme family. ACSL1 is a 75 kDa protein that is associated peripherally with the plasma membrane(Brian M Wiczer, etc., 2006). ACSL1 is abundantly expressed in tissues, such as liver and brown fat, that metabolize substantial amounts of triglycerides as fuel, and as such, a deficiency in ACSL1 function could have a more profound affect in those cells, resulting in hepatosteatosis and potentially increased very low density lipoprotein production by the liver or decreased thermogenic capacity in brown adipose tissue(PMID:19429676). An anti-rat ACSL1 antibody recognized a band of the predicted 68 kDa in high-speed supernatant from rat liver and in human and murine SMCs, monocyte-derived macrophages, and murine peritoneal macrophages (PMID:17259370). It has 2 isoforms produced by alternative splicing. |
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