Phospho-PAK1 (Ser144)/PAK2 (Ser141) Recombinant monoclonal antibody proteintech 85044-1-RR
$449.00
In stock
SKU
85044-1-RR
PAK1 (Ser144), PAK1 (Ser144)/PAK2 (Ser141), PAK2 (Ser141), Phospho-PAK1, Phospho-PAK1 (Ser144)
| Host / Isotype: Rabbit / IgG | Class: Recombinant |
| Reactivity: human, mouse, rat | Immunogen: Peptide Predict reactive species |
| Applications: WB, ELISA | Observed Molecular Weight: 553 aa, 62 kDa |
| Formulation: PBS, Azide, Glycerol | GenBank Accession Number: BC109299 |
| Conjugate: Unconjugated | Gene Symbol: PAK1 |
| Tested Applications: Positive WB detected in | Gene ID (NCBI): 5058 |
| Application: Western Blot (WB) | RRID: Unconjugated |
| Dilution: WB : 1:1000-1:4000 | Conjugate: Liquid |
| Tested Reactivity: Human, Mouse, Rat | Form: Protein A purfication |
| Host / Isotype: Rabbit / IgG | Background Information: The human PAK family is divided into the group I (PAK1 to PAK3) and group II (PAK4 to PAK6). Group I PAK share some domains that are not present in the group II members. In particular, the autoinhibitory domain (AID) is important for regulation of the kinase activity of the group I family members. Autophosphorylation at PAK1 Ser144, or at the equivalent sites for the other PAK, stabilizes the open conformation and sustains high kinase activity. Mutation of tyrosines 131 or 429 is associated with reduced dimerization and enhanced kinase activity. (PMID: 31748572) |
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