Phospho-Myosin Light Chain 2 (Thr18/Ser19) Recombinant monoclonal antibody proteintech 82717-1-RR
$449.00
In stock
SKU
82717-1-RR
MYL12A, MYL12B, P MYL12A, P MYL12B, p MYL9
| Host / Isotype: Rabbit / IgG | Class: Recombinant |
| Reactivity: human, mouse | Immunogen: Peptide Predict reactive species |
| Applications: WB, ELISA | Observed Molecular Weight: 20 kDa |
| Formulation: PBS, Azide, Glycerol | GenBank Accession Number: BC002648 |
| Conjugate: Unconjugated | Gene Symbol: MYL9 |
| Tested Applications: Positive WB detected in | Gene ID (NCBI): 10398 |
| Application: Western Blot (WB) | RRID: AB_3085363 |
| Dilution: WB : 1:5000-1:50000 | Conjugate: Unconjugated |
| Tested Reactivity: Human, Mouse | Form: Liquid |
| Host / Isotype: Rabbit / IgG | Background Information: Myosin II is an actin-binding protein composed of MHC (myosin heavy chain), MLCs/MRLCs (myosin regulatory light chains) and ELCs (essential light chains). The Myosin Light Chains are divided into basic MLC (MLC I) and regulatory MLC (MLC II or Myosin Regulatory Light Chain, MRLC). MRLC can be classified into two major types: : class I MRLC found in muscles (MLC1, MLC2, MLC3, MYL4, MYL5, MYL6, MYL7, etc), and class II MRLCs present in non-muscle cells (such as MYL9, MYL12A, MYL12B). Phosphorylation of myosin II regulatory light chain (MRLC) is important for cell motility and cytokinesis in nonmuscle cells. Phosphorylation of MRLC at Ser19 (1P-MRLC) enhances myosin II activity, which is further enhanced by MRLC diphosphorylation at Thr18/Ser19 (2P-MRLC) in vitro .PMID: 23951055,PMID: 21126233 This antibody can recognize the phosphorylation of three highly homologous Myosin-regulated light chains: MYL12A, MYL12B and MYL9. |
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