Phospho-MEK1 (Ser298) Recombinant monoclonal antibody proteintech 84691-1-RR
$449.00
In stock
SKU
84691-1-RR
p MAP2K1, P MEK1, phos MAP2K1, Phos MEK1, phos-MAP2K1
| Host / Isotype: Rabbit / IgG | Class: Recombinant |
| Reactivity: human | Immunogen: Peptide Predict reactive species |
| Applications: WB, FC (Intra), ELISA | Observed Molecular Weight: 43 kDa |
| Formulation: PBS, Azide, Glycerol | GenBank Accession Number: BC139729 |
| Conjugate: Unconjugated | Gene Symbol: MEK1 |
| Tested Applications: Positive WB detected in | Gene ID (NCBI): 5604 |
| Application: Western Blot (WB) | RRID: ENSG00000169032 |
| Dilution: WB : 1:5000-1:50000 | Conjugate: AB_3672107 |
| Tested Reactivity: Human | Form: Unconjugated |
| Host / Isotype: Rabbit / IgG | Background Information: MAP2K1 encodes MAPK1, also known as MEK1. MEK1 variants can enhance MEK1 expression and ERK1 phosphorylation that together lead to continuous activation of MEK/ERK signaling pathway. MEK1 bind directly to ERK2 through a region in the N terminus of MEK. In addition, a proline-rich (PR) regulatory sequence in MEK is also involved in MEK-ERK association and signal propagation. The coupling between MEK1 and ERK2 is enhanced through phosphorylation on S298 in the MEK1 PR region, whereas phosphorylation on MEK1 T292 releases the complex. MEK1 enzymatic activity is regulated by site-specific phosphorylation that can be activated with phosphorylation of Ser217/Ser221 by Raf kinase or suppressed by phosphorylation of Thr286 and Thr292 by CDK1 and CDK5 or Thr292 and Thr386 by ERK1/2. (PMID:?31972311, PMID:?17928366, PMID:?22177953) |
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