Anti-Human Granzyme B Rabbit Recombinant Antibody proteintech 98070-1-RR
$180.00
In stock
SKU
98070-1-RR
GZMB, 240761G4, Cathepsin G-like 1, CCPI, CGL 1
| Host / Isotype: Rabbit / IgG | Class: Antibody |
| Reactivity: human | Immunogen: granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) |
| Applications: IHC, FC (Intra) | Observed Molecular Weight: BC030195 |
| Formulation: PBS, Azide | GenBank Accession Number: 3002 |
| Conjugate: Unconjugated | Gene Symbol: AB_3672217 |
| Tested Applications: Positive FC (Intra) detected in | Gene ID (NCBI): Unconjugated |
| Application: Flow Cytometry (FC) (INTRA) | RRID: Liquid |
| Dilution: FC (INTRA) : 0.25 ug per 10^6 cells in a 100 ?l suspension | Conjugate: Protein A purfication |
| Tested Reactivity: Human | Form: P10144 |
| Host / Isotype: Recombinant | Background Information: GZMB (Granzyme B) is also named as CGL1, CSPB, CTLA1, GRB and belongs to the Granzyme subfamily. This enzyme is necessary for target cell lysis in cell-mediated immune responses. The cytotoxic lymphocyte protease granzyme B (GzmB) can promote apoptosis through direct processing and activation of members of the caspase family. GzmB can also cleave the BH3-only protein, BID, to promote caspase-independent mitochondrial permeabilization (PMID:17283187). GzmB induces lamin B degradation in isolated nuclei less efficiently than GzmA (PMID:11331782). This full-length protein has 2 glycosylation sites and a signal peptide. Unglycosylated human granzyme B is 26 kDa and high mannose glycosylated is 32 kDa and only 32 kDa or smaller forms of granzyme B are accumulated within nuclei (PMID:8626751). GzmB also forms dimers. |
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