STAT3 Recombinant monoclonal antibody proteintech 80149-1-RR
$449.00
In stock
SKU
80149-1-RR
3H1, Acute-phase response factor, APRF, HIES, STAT 3
| Host / Isotype: Rabbit / IgG | Class: Recombinant |
| Reactivity: human, mouse | Immunogen: Peptide Predict reactive species |
| Applications: WB, IHC, ELISA, ChIP-qPCR | Observed Molecular Weight: 770 aa, 88 kDa |
| Formulation: PBS, Azide, Glycerol | GenBank Accession Number: BC000627 |
| Conjugate: Unconjugated | Gene Symbol: STAT3 |
| Tested Applications: Positive WB detected in | Gene ID (NCBI): 6774 |
| Application: Western Blot (WB) | RRID: AB_2918869 |
| Dilution: WB : 1:1000-1:8000 | Conjugate: Unconjugated |
| Tested Reactivity: Human, Mouse | Form: Liquid |
| Host / Isotype: Rabbit / IgG | Background Information: Signal transducer and activator of transcription 3 (acute-phase response factor) (STAT3, synonyms: APRF, FLJ20882, MGC16063) is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. STAT3 is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. STAT3 mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of STAT3. |
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