OPTN/Optineurin Recombinant monoclonal antibody proteintech 83634-5-RR
$449.00
In stock
SKU
83634-5-RR
Optineurin, OPTN, 240636A7, ALS12, E3-14.7K-interacting protein
| Host / Isotype: Rabbit / IgG | Class: Antibody |
| Reactivity: human | Immunogen: optineurin |
| Applications: WB, IHC, FC (Intra), ELISA | Observed Molecular Weight: 66-70 kDa |
| Formulation: PBS, Azide, Glycerol | GenBank Accession Number: OPTN |
| Conjugate: Unconjugated | Gene Symbol: 10133 |
| Tested Applications: Positive WB detected in | Gene ID (NCBI): AB_3671244 |
| Application: Western Blot (WB) | RRID: Unconjugated |
| Dilution: WB : 1:5000-1:50000 | Conjugate: Liquid |
| Tested Reactivity: Human | Form: Protein A purfication |
| Host / Isotype: Recombinant | Background Information: OPTN, also named as FIP2, GLC1E, HIP7, HYPL, and NRP, plays a neuroprotective role in the eye and optic nerve. It is probably part of the TNF-alpha signaling pathway that can shift the equilibrium toward induction of cell death. OPTN may act by regulating membrane trafficking and cellular morphogenesis via a complex that contains Rab8 and hungtingtin (HD). OPTN may constitute a cellular target for adenovirus E3 14.7, an inhibitor of TNF-alpha functions, thereby affecting cell death. Defects in OPTN cause susceptibility to normal pressure glaucoma (NPG). OPTN mutated in adult-onset primary open angle glaucoma. It supports the protective role of OPTN in the trabecular meshwork. |
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