LAG-3/CD223 Recombinant monoclonal antibody proteintech 80867-1-RR
$449.00
In stock
SKU
80867-1-RR
LAG-3, CD223, 1F14, LAG3, LAG 3
| Host / Isotype: Rabbit / IgG | Class: Recombinant |
| Reactivity: human, mouse | Immunogen: Recombinant protein Predict reactive species |
| Applications: WB, IF, ELISA | Observed Molecular Weight: 57 kDa |
| Formulation: PBS, Azide, Glycerol | GenBank Accession Number: NM_002286 |
| Conjugate: Unconjugated | Gene Symbol: LAG-3 |
| Tested Applications: Positive WB detected in | Gene ID (NCBI): 3902 |
| Application: Western Blot (WB) | RRID: AB_2918917 |
| Dilution: WB : 1:1000-1:8000 | Conjugate: Unconjugated |
| Tested Reactivity: Human, Mouse | Form: Liquid |
| Host / Isotype: Rabbit / IgG | Background Information: LAG-3, also known as CD223, is an immune checkpoint molecule that regulates both T-cell activation and homeostasis. LAG-3 is expressed on activated T cells, NK cells, regulatory T cells, and plasmacytoid dendritic cells. It is a CD4-related molecule that binds MHC class II. LAG-3 plays an important role in modulating T cell expansion and function, and blockade of LAG-3 with monoclonal antibodies can augment T cell function. (PMID: 15634887; 21086108; 28783703) |
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