VE-cadherin/CD144 Recombinant monoclonal antibody proteintech 83766-2-RR
$449.00
In stock
SKU
83766-2-RR
VE-cadherin, CDH5, CD144, Cadherin 5, 7B4 antigen
| Host / Isotype: Rabbit / IgG | Class: Antibody |
| Reactivity: human | Immunogen: cadherin 5, type 2 (vascular endothelium) |
| Applications: WB, IHC, IF/ICC, ELISA | Observed Molecular Weight: 130 kDa, 100 kDa |
| Formulation: PBS, Azide, Glycerol | GenBank Accession Number: VE-cadherin |
| Conjugate: Unconjugated | Gene Symbol: 1003 |
| Tested Applications: Positive WB detected in | Gene ID (NCBI): AB_3662933 |
| Application: Western Blot (WB) | RRID: Unconjugated |
| Dilution: WB : 1:2000-1:10000 | Conjugate: Liquid |
| Tested Reactivity: Human | Form: Protein A purification |
| Host / Isotype: Recombinant | Background Information: Cadherins are a family of transmembrane glycoproteins that mediate calcium-dependent cell-cell adhesion and play an important role in the maintenance of normal tissue architecture. Vascular endothelial cadherin (VE-cadherin), also known as Cadherin-5 (CDH5) or CD144, is a member of the type II classical cadherin family of cell adhesion proteins (PMID: 21269602). VE-cadherin is expressed specifically in endothelial cells and mediates homophilic adhesion in the vascular endothelium (PMID: 1522121; 8555485; 21269602). VE-cadherin plays a role in the organization of lateral endothelial junctions and in the control of permeability properties of vascular endothelium (PMID: 1522121). VE-cadherin has also been shown to be required for angiogenesis (PMID: 16473763; 18162609). The calculated molecular weight of VE-cadherin is 88 kDa and the apparent molecular weight of 120-140 kDa is higher due to post-translational glycosylation and phosphorylation (PMID: 10460833; 29894844). Full-length VE-cadherin can be proteolytically cleaved to generate a fragment of 90-100 kDa (PMID: 9786462; 22064597). |
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