Siglec-7/CD328 Recombinant monoclonal antibody proteintech 84253-4-RR
$449.00
In stock
SKU
84253-4-RR
SIGLEC7, Siglec-7, D siglec, CD328, AIRM-1
| Host / Isotype: Rabbit / IgG | Class: Antibody |
| Reactivity: human | Immunogen: sialic acid binding Ig-like lectin 7 |
| Applications: WB, IHC, ELISA | Observed Molecular Weight: 75 kDa |
| Formulation: PBS, Azide, Glycerol | GenBank Accession Number: Siglec-7 |
| Conjugate: Unconjugated | Gene Symbol: 27036 |
| Tested Applications: Positive WB detected in | Gene ID (NCBI): Unconjugated |
| Application: Western Blot (WB) | RRID: Liquid |
| Dilution: WB : 1:1000-1:8000 | Conjugate: Protein A purfication |
| Tested Reactivity: Human | Form: Q9Y286-1 |
| Host / Isotype: Recombinant | Background Information: Sialic acid binding Ig-like lectin 7 (Siglec-7), also known as CD328 or p75/AIRM-1, is a member of the Siglec family of glycan-recognition proteins. Siglec-7 is a type-I transmembrane protein consisting of three extracellular immunoglobulin-like domains that comprise an N-terminal V-set domain and two C2-set domains, a transmembrane region and a cytoplasmic tail containing two tyrosine residues embodied in immunoreceptor tyrosine-based inhibition motif-like motifs (PMID: 32322597; 10567377). It is mainly expressed on immune cells, with low levels on granulocytes, intermediate levels on monocytes, and relatively high levels on a major subset of natural killer cells and a minor subset of CD8+ T cells (PMID: 10567377). Siglec-7 is an inhibitory receptor that negatively regulates the function of NK cells and modulates the immune response through the interaction of sialic acid-containing ligands (PMID: 27312286). |
Reviews
Write Your Own Review
Related Products
Check items to add to the cart or
