SESN3 Recombinant monoclonal antibody proteintech 84823-3-RR
$449.00
In stock
SKU
84823-3-RR
242189D1, EC:1.11.1.-, SEST3, sestrin 3, Sestrin-3
| Host / Isotype: Rabbit / IgG | Class: Antibody |
| Reactivity: human, mouse | Immunogen: sestrin 3 |
| Applications: WB, IHC, IF/ICC, ELISA | Observed Molecular Weight: 57-60 kDa |
| Formulation: PBS, Azide, Glycerol | GenBank Accession Number: SESN3 |
| Conjugate: Unconjugated | Gene Symbol: 143686 |
| Tested Applications: Positive WB detected in | Gene ID (NCBI): Unconjugated |
| Application: Western Blot (WB) | RRID: Liquid |
| Dilution: WB : 1:5000-1:50000 | Conjugate: Protein A purfication |
| Tested Reactivity: Human, Mouse | Form: P58005 |
| Host / Isotype: Recombinant | Background Information: Sestrins, including sestrin-1 (PA26), sestrin-2 (Hi95), and sestrin-3, are 48 to 65 kDa cystein sulfinyl reductases and modulate peroxide signaling and antioxidant defense. These proteins selectively reduce or repair hyperoxidized forms of typical 2-Cys peroxiredoxins within eukaryotes. Expression of these proteins is regulated by p53, a tumor suppressor protein. Sestrin 3 was identified as a forkhead box O (FoxO) target gene with antioxidant activity. Recently it was reported that sestrin 3 may play an important role in AKT-induced increase in ROS. It might be a promising target in selectively killing cancer cells with high AKT activity levels. |
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