cGAS Polyclonal antibody proteintech 26416-1-AP
$449.00
In stock
SKU
26416-1-AP
2'3'-cGAMP synthase, C6orf150, cGAMP synthase, EC:2.7.7.86, h-cGAS
| Host / Isotype: Rabbit / IgG | Class: Polyclonal |
| Reactivity: Human And More (4) | Immunogen: CatNo: Ag23455 Product name: Recombinant human C6orf150 protein Source: e coli.-derived, PET30a Tag: 6*His Domain: 1-233 aa of BC113608 Sequence: MQPWHGKAMQRASEAGATAPKASARNARGAPMDPNESPAAPEAALPKAGKFGPARKSGSRQKKSAPDTQERPPVRATGARAKKAPQRAQDTQPSDATSAPGAEGLEPPAAREPALSRAGSCRQRGARCSTKPRPPPGPWDVPSPGLPVSAPILVRRDAAPGASKLRAVLEKLKLSRDDISTAAGMVKGVVDHLLLRLKCDSAFRGVGLLNTGSYYEHVKISAPNEFDVMFKLE Predict reactive species |
| Applications: WB, IHC, IF/ICC, IP, ELISA | Observed Molecular Weight: 496 aa, 54 kDa |
| Formulation: PBS, Azide, Glycerol | GenBank Accession Number: BC113608 |
| Conjugate: Unconjugated | Gene Symbol: cGAS |
| Tested Applications: Positive WB detected in | Gene ID (NCBI): 115004 |
| Application: Western Blot (WB) | RRID: AB_2880507 |
| Dilution: WB : 1:40000-1:80000 | Conjugate: Unconjugated |
| Tested Reactivity: Human | Form: Liquid |
| Host / Isotype: Rabbit / IgG | Background Information: cGAS (Cyclic GMP-AMP synthase), also known as C6orf150 or h-cGAS, is a 522 aa protein. cGAS mediates innate immune responses against invading pathogens, or against self-dsDNA, which causes autoimmune disorders. The cGAS sensor not only recognizes cytosolic dsDNA but also synthesizes the second messenger cGAMP from ATP and GTP, which then binds to and activates STING. STING undergoes conformational changes and translocation from the endoplasmic reticulum to the Golgi apparatus to encounter TBK1 and IRF3, eventually triggering the production of type I IFNs. |
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