Presenilin-1-Specific Recombinant monoclonal antibody proteintech 83618-3-RR
$449.00
In stock
SKU
83618-3-RR
PSEN1, Presenilin-1 CTF12, Presenilin-1 CTF subunit, Presenilin-1, EC:3.4.23.-
| Host / Isotype: Rabbit / IgG | Class: Antibody |
| Reactivity: human, rat | Immunogen: presenilin 1 |
| Applications: WB, IHC, IF-P, ELISA | Observed Molecular Weight: 53 kda |
| Formulation: PBS, Azide, Glycerol | GenBank Accession Number: PSEN1 |
| Conjugate: Unconjugated | Gene Symbol: 5663 |
| Tested Applications: Positive WB detected in | Gene ID (NCBI): AB_3671231 |
| Application: Western Blot (WB) | RRID: Unconjugated |
| Dilution: WB : 1:2000-1:10000 | Conjugate: Liquid |
| Tested Reactivity: Human, Rat | Form: Protein A purfication |
| Host / Isotype: Recombinant | Background Information: PSEN1(presenilin-1) is also named as AD3, PS1, PSNL1 and belongs to the peptidase A22A family. It directly influences Netrin/DCC signaling with cell type precision and spatiotemporal specificity, and is a key neural circuit builder that gates the spatiotemporal pattern of guidance signaling, thereby ensuring neural projections occur with high fidelity(PMID:21215373). The 46-kDa PSEN1 holoprotein is cleaved into a D30-kDa N-terminal fragment (NTF) and a D20-kDa C-terminal fragment (CTF) by the 26S proteasome (PMID:10527805). It has 7 isoforms produced by alternative splicing. This antibody is specific to isoform1(53 kDa), isoform2(52 kDa), isoform4(21 kDa), isoform7(49 kDa) of this protein. |
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