Perforin Recombinant monoclonal antibody proteintech 83977-1-RR
$449.00
In stock
SKU
83977-1-RR
241009C10, Cytolysin, FLH2, HPLH2, Lymphocyte pore-forming protein
| Host / Isotype: Rabbit / IgG | Class: Antibody |
| Reactivity: human, mouse | Immunogen: perforin 1 (pore forming protein) |
| Applications: WB, ELISA | Observed Molecular Weight: 65-70 kDa |
| Formulation: PBS, Azide, Glycerol | GenBank Accession Number: Perforin |
| Conjugate: Unconjugated | Gene Symbol: 5551 |
| Tested Applications: Positive WB detected in | Gene ID (NCBI): AB_3671552 |
| Application: Western Blot (WB) | RRID: Unconjugated |
| Dilution: WB : 1:2000-1:10000 | Conjugate: Liquid |
| Tested Reactivity: Human, Mouse | Form: Protein A purification |
| Host / Isotype: Recombinant | Background Information: Perforin (PRF1) is one of the major cytolytic proteins of cytolytic granules. It is known to be a crucial effector molecule in cytolytic T lymphocyte and natural killer cell-mediated cytotoxicity. This protein has structural and functional similarities to complement component C9. Like C9, this protein creates transmembrane tubules and is capable of lysing nonspecifically a variety of target cells. Defects in PRF1 are the cause of familial hemophagocytic lymphohistiocytosis type 2 (FHL2), which is characterized by immune dysregulation with hypercytokinemia and defective natural killer cell function. (PMID: 2417226; 7774276; 2783486; 10583959) |
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