MTHFR Recombinant monoclonal antibody proteintech 83372-7-RR
$449.00
In stock
SKU
83372-7-RR
240348C12, EC:1.5.1.53, Methylenetetrahydrofolate reductase (NADPH)
| Host / Isotype: Rabbit / IgG | Class: Antibody |
| Reactivity: human | Immunogen: 5,10-methylenetetrahydrofolate reductase (NADPH) |
| Applications: WB, FC (Intra), ELISA | Observed Molecular Weight: 75-78 kDa |
| Formulation: PBS, Azide, Glycerol | GenBank Accession Number: MTHFR |
| Conjugate: Unconjugated | Gene Symbol: 4524 |
| Tested Applications: Positive WB detected in | Gene ID (NCBI): AB_3671026 |
| Application: Western Blot (WB) | RRID: Unconjugated |
| Dilution: WB : 1:5000-1:50000 | Conjugate: Liquid |
| Tested Reactivity: Human | Form: Protein A purfication |
| Host / Isotype: Recombinant | Background Information: 5,10-Methylenetetrahydrofolate reductase (MTHFR) is a crucial enzyme in the folate metabolic pathway with a key role in generating methyl groups. MTHFR reduces 5,10-methylenetetrahydrofolate (5,10-methyleneTHF) to 5-methylTHF, the primary carbon donor for methionine production from homocysteine. In humans and mice studies, mutations and polymorphisms in MTHFR are associated with impaired spermatogenesis and male infertility. It has been reported that MTHFR is highly phosphorylated under unperturbed conditions and T34 is the priming phosphorylation site. MTHFR gene has two promoters and isoform (70 kDa and 77 kDa). Although the major form of MTHFR is 77kDa in most tissues, a second isoform of 70kDa was observed after western blotting of human fetal liver and porcine liver. (PMID:?24769206, PMID:?34128976, PMID:?18615588) |
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