IRG1 Recombinant monoclonal antibody proteintech 86725-1-RR
$449.00
In stock
SKU
86725-1-RR
ACOD1, CAD
| Host / Isotype: Rabbit / IgG | Class: Antibody |
| Reactivity: human, mouse | Immunogen: immunoresponsive 1 homolog (mouse) |
| Applications: WB, IF/ICC, ELISA | Observed Molecular Weight: 53 kDa |
| Formulation: PBS, Azide, Glycerol | GenBank Accession Number: IRG1 |
| Conjugate: Unconjugated | Gene Symbol: 730249 |
| Tested Applications: Positive WB detected in | Gene ID (NCBI): Unconjugated |
| Application: Western Blot (WB) | RRID: Liquid |
| Dilution: WB : 1:5000-1:50000 | Conjugate: Protein A purification |
| Tested Reactivity: Human, Mouse | Form: A6NK06 |
| Host / Isotype: Recombinant | Background Information: The host Immune-Responsive Gene 1 (IRG1; also called Acod1) is a mitochondrial enzyme induced under inflammatory conditions that produces the metabolite itaconate by decarboxylating cis-aconitate, a TCA cycle intermediate. Gene expression profiling studies of murine macrophages and microglial cells have revealed that IRG1 is highly expressed under pro-inflammatory conditions. Furthermore, IRG1 is highly expressed in the pregnant uterus during the early events leading to implantation, the specific phase of pregnancy in which high levels of inflammatory cytokines are secreted. IRG1 localizes to the mitochondria and may represent a key link between immunological and metabolic processes. IRG1 has crucial functions in embryonic implantation and neurodegeneration. Also, IRG1 promotes endotoxin tolerance by increasing A20 expression in macrophages via increased ROS production. (PMID: 25640654) |
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