GRB10 Recombinant monoclonal antibody proteintech 81225-1-RR
$449.00
In stock
SKU
81225-1-RR
KIAA0207, Insulin receptor-binding protein Grb-IR, Growth factor receptor-bound protein 10, GRBIR, 1D13
| Host / Isotype: Rabbit / IgG | Class: Antibody |
| Reactivity: human, mouse, rat | Immunogen: growth factor receptor-bound protein 10 |
| Applications: WB, IF/ICC, ELISA | Observed Molecular Weight: 60-70 kDa |
| Formulation: PBS, Azide, Glycerol | GenBank Accession Number: GRB10 |
| Conjugate: Unconjugated | Gene Symbol: 2887 |
| Tested Applications: Positive WB detected in | Gene ID (NCBI): AB_2923710 |
| Application: Western Blot (WB) | RRID: Unconjugated |
| Dilution: WB : 1:5000-1:50000 | Conjugate: Liquid |
| Tested Reactivity: Human, Mouse, Rat | Form: Protein A purification |
| Host / Isotype: Recombinant | Background Information: GRB10 is an adapter protein which modulates coupling of a number of cell surface receptor kinases with specific signaling pathways. GRB10 has three consensus domains including pleckstrin homology (PH) domain, SH2/SH3 domain and Ras-associating domain. By binding to kinases, GRB10 suppresses signals from activated receptors tyrosine kinases, including INSR and IGF1R. It may play a role in mediating ubiquitination of INSR, leading to proteasomal degradation. GRB10 has 4 isoforms with the molecular mass of 60-70 kDa, which are produced by alternative splicing. |
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